NHGRI Technology Development Coordinating Center
Stimulating an interactive culture among Genome Technology Program grantees.
Supporting greater productivity through collaboration.
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Purpose & Goals
Advances in genomic technologies and methods have facilitated research that is producing significant insights into biology and disease. To further these advances, NHGRI supports the Genome Technology program, which aims to accelerate innovation, development, and early dissemination of genomic technologies. The development of completely novel approaches and the refinement of current technologies to achieve orders-of-magnitude improvements are foundational goals of the program. With these goals in mind, the Genome Technology program consists of a growing set of interrelated efforts that enable novel and refined technologies to proceed through discovery and development, towards commercialization and clinical utilization.
The goal of this initiative is to develop new technologies and improve the quality and efficiency of DNA sequencing and direct RNA sequencing through the support of approaches and instrumentation that will significantly advance the field of genomics.
The goal of this initiative is to catalyze the development and advancement of new technologies that can comprehensively analyze genomic features such as methods to evaluate gene regulation and nuclear organization, and the dynamics of genomic features in single and mixed populations of cells.
This initiative is focused on supporting the advancement of novel technologies and methods to inexpensively and accurately synthesize specified sequences of nucleic acids and synthetic constructs at the scale needed for genomics-based research.
This initiative seeks to catalyze technology development that enable generation of protein sequencing data at sufficient scale, speed, cost and accuracy for routine use in studies of genome biology and function, and in biomedical and clinical research.
The NHGRI Technology Development Coordinating Center provides an infrastructure that addresses the need for closer interactions between these efforts. This enables opportunities for collaboration among grantees, accelerated technology innovation, and improved dissemination of program advances and resources to the broader biomedical research community.
Outreach Events
The National Human Genome Research Institute (NHGRI) and the Technology Development Coordinating Center (TDCC) invite you to a three-part webinar series featuring distinguished leaders in genome science and technology development. Rapid advances in genomic analysis have increased the efficiency, accuracy, and depth of biological discovery, and these improvements are driven by innovative approaches in spatial profiling, single-cell genomics, functional genomics, and genome organization.
This series brings together experts whose research continues to expand the frontiers of genome technology. The sessions are designed for postsecondary students, postdoctoral fellows, and biomedical researchers who are seeking a deeper understanding of how emerging tools are developed, applied, and refined. Each event includes scientific presentations and a roundtable discussion that examines current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Recordings of previous TDCC outreach events can be found on our YouTube Channel (www.youtube.com/@genometdcc/).
Revealing Biological Complexity
Through Spatial Profiling
MARCH 26, 2026
Space the Final Frontier: Genomics in the Tissue Context
Fei Chen, Ph.D.
Harvard Stem Cell Institute, The Broad Institute
Comparative Spatial Biology: Mapping of Transcriptional Differences Across Genetic Backgrounds in Mouse Brains
Roy Wollman, Ph.D.
University of California, Los Angeles
Charting Cellular Futures: Lineage Recording
and Regulatory Network Insights
MARCH 31, 2026
Lineage Recording and Barcoding of Monoclonal Models of Early Development
Jay Shendure, MD, Ph.D.
University of Washington, HHMI, Seattle Hub for Synthetic Biology and Brotman Baty Institute for Precision Medicine. (Photo credit to Ron Wurzer/AP Images for HHMI)
Epigenomics: Recording the Past and Predicting the Future
Jason Buenrostro, Ph.D.
Broad Institute, Harvard University
Exploring How Genome Organization Shapes
Biological Function
APRIL 07, 2026
Revealing Additional Layers of cis-Regulatory Codes Governing Transcription Factor Interactions
Martha Bulyk, Ph.D.
Brigham & Women’s Hospital,
Harvard Medical School
RNA Promotes the Formation of Spatial Compartments Throughout the Nucleus
Mitchell Guttman, Ph.D.
California Institute of Technology
Linking Cytosolic Single-Stranded DNA Formation to Fragile X Syndrome Pathology
Wenyi Feng, Ph.D.
SUNY Upstate Medical University
