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Genomic Technology Development
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Project Title
Project Number
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Publications
TDCC Status
In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues
HG012819
JIN, XIN
SCRIPPS RESEARCH INSTITUTE, THE
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Active
Next generation massively multiplexed combinatorial genetic screens
HG012351
MALI, PRASHANT (contact); IDEKER, TREY
UNIVERSITY OF CALIFORNIA, SAN DIEGO
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Active
Multiplexed Analysis of the Epitranscriptome
HG012170
STENGEL, GUDRUN
ALIDA BIOSCIENCES, INC.
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Active
Mechanisms of Transcriptional Control Revealed by Nascent Transcript Sequencing
HG007173
CHURCHMAN, LEE STIRLING
HARVARD MEDICAL SCHOOL
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Active
Scalable, quantitative, single-cell CRISPR screens
HG012230
NORMAN, THOMAS
SLOAN-KETTERING INST CAN RESEARCH
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Active
Bi-functional photo-crosslinking (BFPX) for genome-wide study of protein-nucleic acid interactions
HG012419
CHEN, LIN
UNIVERSITY OF SOUTHERN CALIFORNIA
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Active
Advancing an Innovative NGS Approach to Discover and Investigate Histone Tail Proteolysis
HG012833
RICE, JUDD C
UNIVERSITY OF SOUTHERN CALIFORNIA
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Active
Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation
HG012216
JOVANOVIC, MARKO (contact); GUTTMAN, MITCHELL
COLUMBIA UNIV NEW YORK MORNINGSIDE
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Active
Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologies
HG012357
KALHOR, REZA
JOHNS HOPKINS UNIVERSITY
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Active
Targets and functions of the mammalian snoRNAome
HG012780
PAN, TAO (contact); HE, CHUAN
UNIVERSITY OF CHICAGO
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Active
CRISPR-based genome tagging of iPS Cells for stain-free multicolor live cell analysis
HG012241
PEREZ-LEAL, OSCAR
TEMPLE UNIV OF THE COMMONWEALTH
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Active
Single-cell and single-molecule profiling of protein-DNA interactions by MACHA
HG012423
POTT, SEBASTIAN (contact); IKEGAMI, KOHTA
UNIVERSITY OF CHICAGO
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Active
Ultrasensitive multiomic platform using epitope-targeted DNA methylation mapping
HG011875
KEOGH, MICHAEL-CHRISTOPHER (contact); VENTERS, BRYAN J
EPICYPHER, INC.
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Active
Semi-permeable capsules for high-throughput single cell multi-omics
HG012771
KLEIN, ALLON MOSHE
HARVARD MEDICAL SCHOOL
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Active
Methods for Mapping Genetic Regulatory Elements in Single Cells and Single Molecules
HG012383
STREETS, AARON
UNIVERSITY OF CALIFORNIA BERKELEY
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Active
High-throughput analysis of the effects of gene promoters and chromosomal environments on single-cell gene expression
HG012304
COHEN, BARAK A
WASHINGTON UNIVERSITY
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Active
A single-strand ligation approach for concomitant DNA and RNA next-generation sequencing from low abundance inputs
HG011877
RAO, VARSHA
CLARET BIOSCIENCE, LLC
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Active
A scalable kit-based assay for multi-omic analyses of transcriptional protein binding and chromatin interactions from ultra-low input frozen and FFPE samples at single-cell resolution
HG011897
SCHMITT, ANTHONY
ARIMA GENOMICS, INC.
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Active
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement
HG011850
SINCLAIR, DAVID A
HARVARD MEDICAL SCHOOL
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Active
Bacteriophage Mu as Tool to Study Genome Organization in Bacteria and Eukaryotes
HG011838
HARSHEY, RASIKA M (contact); FREDDOLINO, PETER L
UNIVERSITY OF TEXAS, AUSTIN
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Active
High-throughput detection of transcriptomic and epitranscriptomic variation and kinetics using MarathonRT
HG011868
PYLE, ANNA MARIE (contact); GRAVELEY, BRENTON R
YALE UNIVERSITY
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Active
STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites
HG011864
YEO, EUGENE WEI-MING
UNIVERSITY OF CALIFORNIA, SAN DIEGO
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Active
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations
HG011866
BINTU, LACRAMIOARA (contact); BASSIK, MICHAEL C
STANFORD UNIVERSITY
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Active
RNA targeting tools with novel specific RNA-guided RNA-targeting CRISPR effectors
HG011857
GOOTENBERG, JONATHAN SAMUEL (contact); ABUDAYYEH, OMAR O
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
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Active
Nanopore based profiling of epigenetic state
HG009190
TIMP, WINSTON GEORGE
JOHNS HOPKINS UNIVERSITY
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Active
Protein tagging at scale to enable functional genomic studies
HG011855
CHAVEZ, ALEJANDRO
COLUMBIA UNIVERSITY HEALTH SCIENCES
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Active
A transposase system for integrative ChIP-exo and ATAC-seq analysis at single-cell resolution
HG010211
ZEITLINGER, JULIA
STOWERS INSTITUTE FOR MEDICAL RESEARCH
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Active
Massively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial Indexing
HG011229
KENNEDY, SCOTT ROBERT (contact); SEELIG, GEORG
UNIVERSITY OF WASHINGTON
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Active
Versatile, exponentially scalable methods for single cell molecular profiling
HG010632
SHENDURE, JAY ASHOK (contact); TRAPNELL, BRUCE COLSTON
UNIVERSITY OF WASHINGTON
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Active
Development of methods for multi-omic analysis of DNA methylation and chromatin architecture in single cells
HG010634
ECKER, JOSEPH R (contact); DIXON, JESSE R
SALK INSTITUTE FOR BIOLOGICAL STUDIES
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Active
TempO-Seq Profiling of RNA Epitranscriptomic Modifications
HG009763
SELIGMANN, BRUCE E.
BIOSPYDER TECHNOLOGIES, INC.
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Active
Non-destructive epigenetic sequencing with DNA deaminase enzymes
HG010646
KOHLI, RAHUL MANU (contact); WU, HAO
UNIVERSITY OF PENNSYLVANIA
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Active
A single cell spatial genomics platform for multi-modal characterization of tissue organization
HG010647
CHEN, FEI (contact); MACOSKO, EVAN Z
BROAD INSTITUTE, INC.
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Active
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissue
HG011245
WANG, SIYUAN
YALE UNIVERSITY
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Active
Mapping gene-by-environment interactions using multiplexed single cell RNA-sequencing
HG011239
YE, CHUN JIMMIE
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
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Active
Development of efficient quantitative chromatin profiling in kit and high-throughput formats
HG010640
VENTERS, BRYAN J (contact); KEOGH, MICHAEL-CHRISTOPHER
EPICYPHER, INC.
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Complete
Arrayed single-cell readout of pooled genetic perturbation libraries
HG009283
BLAINEY, PAUL CLARK
BROAD INSTITUTE, INC.
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Complete
Next-generation Functional Genetic Screening of Un-screenable Traits
HG009285
MALI, PRASHANT (contact); TAMAYO, PABLO ; ZHANG, KUN
UNIVERSITY OF CALIFORNIA, SAN DIEGO
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Complete
Programmable RNA-targeting tools
HG009761
ZHANG, FENG
BROAD INSTITUTE, INC.
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Complete
AVATAR: highly parallel analysis of variation in transcription factors and their DNA binding sites
HG010200
BULYK, MARTHA L
BRIGHAM AND WOMEN’S HOSPITAL
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Complete
Circular RNA as a platform for genome-wide microRNA sponge libraries
HG011214
PICKERING, BRIAN FREDERICK
CHIMERNA THERAPEUTICS INC.
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Complete
Orthocoding for Spatial Sequencing
HG011231
SALZMAN, JULIA; FORDYCE, POLLY MORRELL; ROHATGI, RAJAT
STANFORD UNIVERSITY
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Complete
Drop-BS: high-throughput single-cell bisulfite sequencing on a microfluidic droplet platform
HG010195
LU, CHANG
VIRGINIA POLYTECHNIC INST AND ST UNIV
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Complete
Epi-seq: Multiplexed ChIP-seq for personalized medicine and drug discovery
HG010237
JELINEK, MARY ANNE
ACTIVE MOTIF, INC.
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Complete
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