Functional Genomics

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Project Title Project Number Contact PI / Project Leader Organization Name Publications TDCC Status
Next generation massively multiplexed combinatorial genetic screens HG012351 MALI, PRASHANT (contact); IDEKER, TREY UNIVERSITY OF CALIFORNIA, SAN DIEGO View publication Active
Mechanisms of Transcriptional Control Revealed by Nascent Transcript Sequencing HG007173 CHURCHMAN, LEE STIRLING HARVARD MEDICAL SCHOOL View publication Active
Bi-functional photo-crosslinking (BFPX) for genome-wide study of protein-nucleic acid interactions HG012419 CHEN, LIN UNIVERSITY OF SOUTHERN CALIFORNIA View publication Active
Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation HG012216 JOVANOVIC, MARKO (contact); GUTTMAN, MITCHELL COLUMBIA UNIV NEW YORK MORNINGSIDE View publication Active
Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologies HG012357 KALHOR, REZA JOHNS HOPKINS UNIVERSITY View publication Active
Targets and functions of the mammalian snoRNAome HG012780 PAN, TAO (contact); HE, CHUAN UNIVERSITY OF CHICAGO View publication Active
CRISPR-based genome tagging of iPS Cells for stain-free multicolor live cell analysis HG012241 PEREZ-LEAL, OSCAR TEMPLE UNIV OF THE COMMONWEALTH View publication Active
Single-cell and single-molecule profiling of protein-DNA interactions by MACHA HG012423 POTT, SEBASTIAN (contact); IKEGAMI, KOHTA UNIVERSITY OF CHICAGO View publication Active
Methods for Mapping Genetic Regulatory Elements in Single Cells and Single Molecules HG012383 STREETS, AARON UNIVERSITY OF CALIFORNIA BERKELEY View publication Active
High-throughput analysis of the effects of gene promoters and chromosomal environments on single-cell gene expression HG012304 COHEN, BARAK A WASHINGTON UNIVERSITY View publication Active
A scalable kit-based assay for multi-omic analyses of transcriptional protein binding and chromatin interactions from ultra-low input frozen and FFPE samples at single-cell resolution HG011897 SCHMITT, ANTHONY ARIMA GENOMICS, INC. View publication Active
High-throughput detection of transcriptomic and epitranscriptomic variation and kinetics using MarathonRT HG011868 PYLE, ANNA MARIE (contact); GRAVELEY, BRENTON R YALE UNIVERSITY View publication Active
STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites HG011864 YEO, EUGENE WEI-MING UNIVERSITY OF CALIFORNIA, SAN DIEGO View publication Active
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations HG011866 BINTU, LACRAMIOARA (contact); BASSIK, MICHAEL C STANFORD UNIVERSITY View publication Active
RNA targeting tools with novel specific RNA-guided RNA-targeting CRISPR effectors HG011857 GOOTENBERG, JONATHAN SAMUEL (contact); ABUDAYYEH, OMAR O MASSACHUSETTS INSTITUTE OF TECHNOLOGY View publication Active
Protein tagging at scale to enable functional genomic studies HG011855 CHAVEZ, ALEJANDRO COLUMBIA UNIVERSITY HEALTH SCIENCES View publication Active
TempO-Seq Profiling of RNA Epitranscriptomic Modifications HG009763 SELIGMANN, BRUCE E. BIOSPYDER TECHNOLOGIES, INC. View publication Active
Mapping gene-by-environment interactions using multiplexed single cell RNA-sequencing HG011239 YE, CHUN JIMMIE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO View publication Active
Arrayed single-cell readout of pooled genetic perturbation libraries HG009283 BLAINEY, PAUL CLARK BROAD INSTITUTE, INC. View publication Complete
Next-generation Functional Genetic Screening of Un-screenable Traits HG009285 MALI, PRASHANT (contact); TAMAYO, PABLO ; ZHANG, KUN UNIVERSITY OF CALIFORNIA, SAN DIEGO View publication Complete
Programmable RNA-targeting tools HG009761 ZHANG, FENG BROAD INSTITUTE, INC. View publication Complete
AVATAR: highly parallel analysis of variation in transcription factors and their DNA binding sites HG010200 BULYK, MARTHA L BRIGHAM AND WOMEN’S HOSPITAL View publication Complete
Circular RNA as a platform for genome-wide microRNA sponge libraries HG011214 PICKERING, BRIAN FREDERICK CHIMERNA THERAPEUTICS INC. View publication Complete

in conjunction with

The Technology Development Coordinating Center is supported by NHGRI Project U24HG011735 and The Jackson Laboratory.

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