Single-Cell Methods

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Project Title Project Number Contact PI / Project Leader Organization Name Publications TDCC Status
Self-Evolvr: self-refreshing molecular barcodes using CRISPR-self-guided mutagenesis HG014016 BAYM, MICHAEL HARVARD MEDICAL SCHOOL View publication Active
Pioneering assays for spatially-resolved single-cell multiomics HG013294 PHAM, LIN SURVEY GENOMICS, INC. View publication Active
Smart Laser Capturing Microscope for Genome Wide Single Cell Spatial Transcriptomics HG014004 CANG, HU (contact); SUN, SHA UNIVERSITY OF CALIFORNIA-IRVINE View publication Active
Expansion genomics for high-resolution single-cell and spatial epigenomics HG013679 BUENROSTRO, JASON DANIEL HARVARD UNIVERSITY View publication Active
DNA-optical barcoding technology for spatiotemporal single-cell analysis HG013591 KWOK, SHELDON J J LASE INNOVATION INC. View publication Active
A novel flexible approach for high-throughput single-cell phenotyping and genotyping HG013448 SOUMILLON, MAGALI FLEXOMICS LLC View publication Active
Light-Seq: Spatially targeted profiling of transcriptomic states in cells and tissue HG012926 YIN, PENG HARVARD UNIVERSITY View publication Active
Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologies HG012357 KALHOR, REZA JOHNS HOPKINS UNIVERSITY View publication Active
Methods for Mapping Genetic Regulatory Elements in Single Cells and Single Molecules HG012383 STREETS, AARON UNIVERSITY OF CALIFORNIA BERKELEY View publication Active
High-throughput analysis of the effects of gene promoters and chromosomal environments on single-cell gene expression HG012304 COHEN, BARAK A WASHINGTON UNIVERSITY View publication Active
STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites HG011864 YEO, EUGENE WEI-MING UNIVERSITY OF CALIFORNIA, SAN DIEGO View publication Active
Scalable, quantitative, single-cell CRISPR screens HG012230 NORMAN, THOMAS SLOAN-KETTERING INST CAN RESEARCH View publication Complete
Single-cell and single-molecule profiling of protein-DNA interactions by MACHA HG012423 POTT, SEBASTIAN (contact); IKEGAMI, KOHTA UNIVERSITY OF CHICAGO View publication Complete
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement HG011850 SINCLAIR, DAVID A HARVARD MEDICAL SCHOOL View publication Complete
Arrayed single-cell readout of pooled genetic perturbation libraries HG009283 BLAINEY, PAUL CLARK BROAD INSTITUTE, INC. View publication Complete
A transposase system for integrative ChIP-exo and ATAC-seq analysis at single-cell resolution HG010211 ZEITLINGER, JULIA STOWERS INSTITUTE FOR MEDICAL RESEARCH View publication Complete
Massively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial Indexing HG011229 KENNEDY, SCOTT ROBERT (contact); SEELIG, GEORG UNIVERSITY OF WASHINGTON View publication Complete
Orthocoding for Spatial Sequencing HG011231 SALZMAN, JULIA; FORDYCE, POLLY MORRELL; ROHATGI, RAJAT STANFORD UNIVERSITY View publication Complete
Drop-BS: high-throughput single-cell bisulfite sequencing on a microfluidic droplet platform HG010195 LU, CHANG VIRGINIA POLYTECHNIC INST AND ST UNIV View publication Complete
Mapping gene-by-environment interactions using multiplexed single cell RNA-sequencing HG011239 YE, CHUN JIMMIE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO View publication Complete

in conjunction with

The Technology Development Coordinating Center is supported by NHGRI Project U24HG011735 and The Jackson Laboratory.

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