Sequencing Technology Development Archives

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Project Title	Project Number	Contact PI / Project Leader	Organization Name	Publications	TDCC Status
A Novel Instrument and Consumables for Quality Control in Next Generation Sequencing	HG014079	REED, JASON C	EVIZIA INC	View publication	Active
Super-resolution single-molecule sequencing by observing the dynamic hybridization of a repertoire of oligonucleotides to DNA targets	HG013911	MIR, KALIM ULLAH	XGENOMES CORP.	View publication	Active
High-throughput Direct Sequencing and Quantitative Mapping of RNA Modifications using Mass Spectrometry	HG013624	ZHANG, SHENGLONG	DIRECTSEQ BIOSCIENCES, INC.	View publication	Active
High-throughput size-selection system for long-read sequencing library preparation	HG012531	BOLES, CHRIS	SAGE SCIENCE, INC.	View publication	Active
MFB: Integrating LC-MS/MS and Nanopore Sequencing Platforms to Enable the Direct and Quantitative Detection of RNA Modifications	HG013876	KOUTMOU, KRISTIN S	UNIVERSITY OF MICHIGAN AT ANN ARBOR	View publication	Active
Twice reading of RNA by direct nanopore sequencing	HG013302	HOU, YA-MING	THOMAS JEFFERSON UNIVERSITY	View publication	Active
Re-Reading RNA to Obtain High Accuracy	HG012858	SCHIBEL, ANNA	ELECTRONIC BIOSCIENCES, INC.	View publication	Active
Direct RNA sequencing using electo-optical zero mode waveguides and custom click fluorescent nucleotides	HG013304	WANUNU, MENI	NORTHEASTERN UNIVERSITY	View publication	Active
Synthetic mRNA Control Set for Nanopore-Based Pseudouridine Modification Profiling in Human Transcriptomes	HG012856	ROUHANIFARD, SARA	NORTHEASTERN UNIVERSITY	View publication	Active
Developing a robust method for analyzing transcription factor mediated chromatin interactions	HG012627	CHEN, LIN	UNIVERSITY OF SOUTHERN CALIFORNIA	View publication	Active
Development of Next-Generation Mass Spectrometry-based de novo RNA Sequencing for all Modifications	HG012853	ZHANG, SHENGLONG	NEW YORK INST OF TECHNOLOGY	View publication	Active
Telomere-to-telomere assemblies of human genomes	HG011274	MIGA, KAREN HAYDEN	UNIVERSITY OF CALIFORNIA SANTA CRUZ	View publication	Active
Enzymeless, controlled electrostatic ratcheting in solid-state nanopores	HG012413	SHEPARD, KENNETH L (contact); DRNDIC, MARIJA	COLUMBIA UNIV NEW YORK MORNINGSIDE	View publication	Active
High Accuracy Nanopore Sequencing	HG005115	GUNDLACH, JENS	UNIVERSITY OF WASHINGTON	View publication	Active
Advancing an Innovative NGS Approach to Discover and Investigate Histone Tail Proteolysis	HG012833	RICE, JUDD C	UNIVERSITY OF SOUTHERN CALIFORNIA	View publication	Complete
Sequencing the Mono-Methylated Derivatives of Cytidine	HG012850	ERVIN, ERIC	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
METHYL-SENTRY: Proposed feasibility study of a nanopore diagnostic tool with rapid automated measurement of cell free DNA methylation state for clinical cancer evaluation	HG012724	NIEDZWIECKI, DAVID	GOEPPERT, LLC	View publication	Complete
Single molecule DNA/RNA sequencing technology based on a parallel Raman scattering readout in a coupled nanochannel/nanopore system	HG011608	BRUECK, STEVEN	ARMONICA TECHNOLOGIES, INC.	View publication	Complete
Advanced Parallel Readers for DNA Sequencing Through a 2D Nanopore	HG012395	DRNDIC, MARIJA	UNIVERSITY OF PENNSYLVANIA	View publication	Complete
Novel Chemical Probes for Sequencing Multiple DNA Modifications at Single-Nucleotide Resolution	HG012412	ZHAO, LINLIN	UNIVERSITY OF CALIFORNIA RIVERSIDE	View publication	Complete
Two readers for RNA	HG012364	SCHIBEL, ANNA	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
Nanoscale Tools for Inosine Sequencing	HG012409	ERVIN, ERIC	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
Ion Fountain Nanopore Readers for High-Resolution DNA and RNA Sequencing	HG011689	WANUNU, MENI	NORTHEASTERN UNIVERSITY	View publication	Complete
DNA barcoding via multi-scan and step control in dual-pore tug-of-war	HG011236	REISNER, WALTER (contact); DUNBAR, WILLIAM BRUCE; SLADEK, ROBERT	MCGILL UNIVERSITY	View publication	Complete
On-site, high-fidelity target sequencing and absolute quantitation for HIV-1 surveillance	HG010318	KIM, SANGGU	OHIO STATE UNIVERSITY	View publication	Complete
Single-chain MspA for nanopore sequencing of DNA	HG010543	NIEDERWEIS, MICHAEL	UNIVERSITY OF ALABAMA AT BIRMINGHAM	View publication	Complete
Novel sequencing by synthesis platform to greatly reduce the cost of nucleic acid sequencing	HG010558	PRATT, MARK	ULTIMA GENOMICS, INC.	View publication	Complete
RNA Sequencing Via Single Reverse Transcript Assessments	HG011070	GERMAN, SEAN	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
Conductance Fluctuations: A New Approach to Sequencing?	HG010522	LINDSAY, STUART	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	View publication	Complete
Nanopore Based Direct BAT-25 Microsatellite Sequencing	HG010435	SCHIBEL, ANNA	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
Improving Throughput of Long Reads with High Consensus Base Accuracy to Resolve Repetitive DNAs	HG010548	MIGA, KAREN HAYDEN	UNIVERSITY OF CALIFORNIA SANTA CRUZ	View publication	Complete
LC/MS-Based Direct RNA Sequencing with Concomitant Capability to Sequence Multiple Base Modifications at Single-base Resolution	HG011099	ZHANG, SHENGLONG	NEW YORK INST OF TECHNOLOGY	View publication	Complete
DNA Sequencing with novel 2D FET-nanopore devices	HG010536	DRNDIC, MARIJA	UNIVERSITY OF PENNSYLVANIA	View publication	Complete
Exonuclease Epigenetic Sequencing	HG010049	ERVIN, ERIC	ELECTRONIC BIOSCIENCES, INC.	View publication	Complete
High-accuracy, long-range sequencing for HIV-1 genotyping	HG010108	KIM, SANGGU	OHIO STATE UNIVERSITY	View publication	Complete
Direct Determination of Multiple Specific Forms of DNA Chemical Modifications in Human Genome	HG011095	FANG, GANG	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	View publication	Complete
Computational Design Engine for Accurate and Efficient Sequencing of DNA and RNA	HG002776	MUTHUKUMAR, MURUGAPPAN	UNIVERSITY OF MASSACHUSETTS AMHERST	View publication	Complete
Direct nanopore detection of modified RNA to probe structure and dynamics	HG010538	TIMP, WINSTON GEORGE	JOHNS HOPKINS UNIVERSITY	View publication	Complete
Exploring 3Dpol for RNA sequencing in real time	HG011120	HOU, YA-MING	THOMAS JEFFERSON UNIVERSITY	View publication	Complete
Single-cell direct RNA sequencing using electrical zero-mode waveguides and engineered reverse transcriptases	HG011087	WANUNU, MENI	NORTHEASTERN UNIVERSITY	View publication	Complete
Chemically Tuned Silicon Nitride Nanopores for Nucleic Acid Sequencing	HG011096	DWYER, JASON RODGER	UNIVERSITY OF RHODE ISLAND	View publication	Complete
Sequencing by Direct Electrical Measurements of Polymerase Fluctuations	HG011079	LINDSAY, STUART	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	View publication	Complete
Novel sequencing by synthesis chemistry to further reduce the cost of nucleic acid sequencing	HG011060	MAZUR, DANIEL JOSEPH	ULTIMA GENOMICS, INC.	View publication	Complete
Improving biological nanopores for precision nucleic acid sequencing using a computational microscope	HG011741	AKSIMENTIEV, ALEKSEI (contact); CHEN, MIN	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	View publication	Complete
A Unified Nanopore Platform for Direct Sequencing of Individual Full Length RNA Strands Bearing Modified Nucleotides	HG010053	AKESON, MARK A	UNIVERSITY OF CALIFORNIA SANTA CRUZ	View publication	Complete
Single-Molecule Electronic Nucleic Acid Sequencing-by-Synthesis Using Novel Tagged Nucleotides and Nanopore Constructs	HG010514	JU, JINGYUE (contact); CHURCH, GEORGE M; KALACHIKOV, SERGEY	COLUMBIA UNIV NEW YORK MORNINGSIDE	View publication	Complete